Rituximab Maintenance Therapy After Autologous Stem-Cell Transplantation in Patients With Relapsed CD20+ Diffuse Large B-Cell Lymphoma: Final Analysis of the Collaborative Trial in Relapsed Aggressive Lymphoma
Identifieur interne : 005945 ( Main/Exploration ); précédent : 005944; suivant : 005946Rituximab Maintenance Therapy After Autologous Stem-Cell Transplantation in Patients With Relapsed CD20+ Diffuse Large B-Cell Lymphoma: Final Analysis of the Collaborative Trial in Relapsed Aggressive Lymphoma
Auteurs : Christian Gisselbrecht [France] ; Norbert Schmitz [Allemagne] ; Nicolas Mounier [France] ; Devinder Singh Gill [Australie] ; David C. Linch [Royaume-Uni] ; Marek Trneny [République tchèque] ; Andre Bosly [Belgique] ; Noel J. Milpied [France] ; John Radford [Royaume-Uni] ; Nicolas Ketterer [Suisse] ; Ofer Shpilberg [Israël] ; Ulrich Dührsen [Allemagne] ; Hans Hagberg [Suède] ; David D. Ma [Australie] ; Andreas Viardot [France] ; Ray Lowenthal [Australie] ; Josette Briere [France] ; Gilles Salles [France] ; Craig H. Moskowitz [États-Unis] ; Bertram Glass [Allemagne]Source :
- Journal of clinical oncology [ 0732-183X ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Rituximab, Traitement entretien, Cellule hématopoïétique, Lymphome diffus à grandes cellules B, Cellule souche, Homme, Immunothérapie, Récidive, Essai clinique, Haute malignité, Cancérologie, Anticancéreux, Antigène CD20, Autogreffe de cellules souches hématopoïétiques, Hémopathie lymphoïde B, Hémopathie maligne lymphoïde.
- Wicri :
- topic : Cellule souche, Homme.
English descriptors
- KwdEn :
Abstract
Purpose The standard treatment for relapsed diffuse large B-cell lymphoma (DLBCL) is salvage chemotherapy followed by high-dose therapy and autologous stem-cell transplantation (ASCT). The impact of maintenance rituximab after ASCT is not known. Patients and Methods In total, 477 patients with CD20+ DLBCL who were in their first relapse or refractory to initial therapy were randomly assigned to one of two salvage regimens. After three cycles of salvage chemotherapy, the responding patients received high-dose chemotherapy followed by ASCT. Then, 242 patients were randomly assigned to either rituximab every 2 months for 1 year or observation. Results After ASCT, 122 patients received rituximab, and 120 patients were observed only. The median follow-up time was 44 months. The 4-year event-free survival (EFS) rates after ASCT were 52% and 53% for the rituximab and observation groups, respectively (P = .7). Treatment with rituximab was associated with a 15% attributable risk of serious adverse events after day 100, with more deaths (six deaths v three deaths in the observation arm). Several factors affected EFS after ASCT (P< .05), including relapsed disease within 12 months (EFS: 46% v 56% for relapsed disease after 12 months), secondary age-adjusted International Prognostic Index (saalPI) more than 1 (EFS: 37% v 61 % for saalPI < 1), and prior treatment with rituximab (EFS: 47% v 59% for no prior rituximab). A significant difference in EFS between women (63%) and men (46%) was also observed in the rituximab group. In the Cox model for maintenance, the saalPI was a significant prognostic factor (P < .001), as was male sex (P = .01). Conclusion In relapsed DLBCL, we observed no difference between the control group and the rituximab maintenance group and do not recommend rituximab after ASCT.
Url:
Affiliations:
- Allemagne, Australie, Belgique, France, Israël, Royaume-Uni, République tchèque, Suisse, Suède, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Bohême centrale, Canton de Vaud, District de Tübingen, Grand Londres, Grand Manchester, Hambourg, Provence-Alpes-Côte d'Azur, Rhône-Alpes, Île-de-France
- Hambourg, Lausanne, Londres, Lyon, Manchester, Nice, Paris, Prague, Ulm
- University College de Londres, Université de Manchester
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000D10
- to stream PascalFrancis, to step Curation: 005154
- to stream PascalFrancis, to step Checkpoint: 000D97
- to stream Main, to step Merge: 005C32
- to stream Pmc, to step Corpus: 001950
- to stream Pmc, to step Curation: 001809
- to stream Pmc, to step Checkpoint: 001D81
- to stream Ncbi, to step Merge: 001015
- to stream Ncbi, to step Curation: 001015
- to stream Ncbi, to step Checkpoint: 001015
- to stream Main, to step Merge: 005473
- to stream Main, to step Curation: 005945
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Rituximab Maintenance Therapy After Autologous Stem-Cell Transplantation in Patients With Relapsed CD20<sup>+</sup> Diffuse Large B-Cell Lymphoma: Final Analysis of the Collaborative Trial in Relapsed Aggressive Lymphoma</title><author><name sortKey="Gisselbrecht, Christian" sort="Gisselbrecht, Christian" uniqKey="Gisselbrecht C" first="Christian" last="Gisselbrecht">Christian Gisselbrecht</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôpital Saint Louis</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schmitz, Norbert" sort="Schmitz, Norbert" uniqKey="Schmitz N" first="Norbert" last="Schmitz">Norbert Schmitz</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Asklepios Klinik St Georg</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Mounier, Nicolas" sort="Mounier, Nicolas" uniqKey="Mounier N" first="Nicolas" last="Mounier">Nicolas Mounier</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre Hospitalier Universitaire de l'Archet</s1><s2>Nice</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Singh Gill, Devinder" sort="Singh Gill, Devinder" uniqKey="Singh Gill D" first="Devinder" last="Singh Gill">Devinder Singh Gill</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Princess Alexandra Hospital</s1><s2>Woodville, South Australia</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Princess Alexandra Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Linch, David C" sort="Linch, David C" uniqKey="Linch D" first="David C." last="Linch">David C. Linch</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>University College London, Cancer Institute</s1><s2>London</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Trneny, Marek" sort="Trneny, Marek" uniqKey="Trneny M" first="Marek" last="Trneny">Marek Trneny</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Charles University General Hospital</s1><s2>Prague</s2><s3>CZE</s3><sZ>6 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Bosly, Andre" sort="Bosly, Andre" uniqKey="Bosly A" first="Andre" last="Bosly">Andre Bosly</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Universite Catholique de Louvain Mont-Godinne</s1><s2>Yvoir</s2><s3>BEL</s3><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Universite Catholique de Louvain Mont-Godinne</wicri:noRegion></affiliation></author><author><name sortKey="Milpied, Noel J" sort="Milpied, Noel J" uniqKey="Milpied N" first="Noel J." last="Milpied">Noel J. Milpied</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hôpital Haut-Leveque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hôpital Haut-Leveque</wicri:noRegion><wicri:noRegion>Hôpital Haut-Leveque</wicri:noRegion></affiliation></author><author><name sortKey="Radford, John" sort="Radford, John" uniqKey="Radford J" first="John" last="Radford">John Radford</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>University of Manchester, Christie Hospital National Health Service Trust</s1><s2>Manchester</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Ketterer, Nicolas" sort="Ketterer, Nicolas" uniqKey="Ketterer N" first="Nicolas" last="Ketterer">Nicolas Ketterer</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Clinique Bois-Cerf</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>10 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Shpilberg, Ofer" sort="Shpilberg, Ofer" uniqKey="Shpilberg O" first="Ofer" last="Shpilberg">Ofer Shpilberg</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Davidoff Center, Rabin Medical Center, Beilinson Hospital</s1><s2>Petah Tikva</s2><s3>ISR</s3><sZ>11 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Petah Tikva</wicri:noRegion></affiliation></author><author><name sortKey="Duhrsen, Ulrich" sort="Duhrsen, Ulrich" uniqKey="Duhrsen U" first="Ulrich" last="Dührsen">Ulrich Dührsen</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Universitatsklinikum Essen, Essen; Andreas Viardot, Universitätsklinik Ulm</s1><s2>Ulm</s2><s3>DEU</s3><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Hagberg, Hans" sort="Hagberg, Hans" uniqKey="Hagberg H" first="Hans" last="Hagberg">Hans Hagberg</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Akademiska Sjukhuset</s1><s2>Uppsala</s2><s3>SWE</s3><sZ>13 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Akademiska Sjukhuset</wicri:noRegion></affiliation></author><author><name sortKey="Ma, David D" sort="Ma, David D" uniqKey="Ma D" first="David D." last="Ma">David D. Ma</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>St Vincent's Hospital Sydney</s1><s2>Darlinghurst, New South Wales</s2><s3>AUS</s3><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>St Vincent's Hospital Sydney</wicri:noRegion></affiliation></author><author><name sortKey="Viardot, Andreas" sort="Viardot, Andreas" uniqKey="Viardot A" first="Andreas" last="Viardot">Andreas Viardot</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôpital Saint Louis</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lowenthal, Ray" sort="Lowenthal, Ray" uniqKey="Lowenthal R" first="Ray" last="Lowenthal">Ray Lowenthal</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Royal Hobart Hospital</s1><s2>Tasmania</s2><s3>AUS</s3><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Royal Hobart Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Briere, Josette" sort="Briere, Josette" uniqKey="Briere J" first="Josette" last="Briere">Josette Briere</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôpital Saint Louis</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Hospices Civils de Lyon and Universite de Lyon</s1><s2>Lyon</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Moskowitz, Craig H" sort="Moskowitz, Craig H" uniqKey="Moskowitz C" first="Craig H." last="Moskowitz">Craig H. Moskowitz</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Memorial Sloan-Kettering Cancer Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Memorial Sloan-Kettering Cancer Center</wicri:noRegion></affiliation></author><author><name sortKey="Glass, Bertram" sort="Glass, Bertram" uniqKey="Glass B" first="Bertram" last="Glass">Bertram Glass</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Asklepios Klinik St Georg</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0049270</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 13-0049270 INIST</idno><idno type="RBID">Pascal:13-0049270</idno><idno type="wicri:Area/PascalFrancis/Corpus">000D10</idno><idno type="wicri:Area/PascalFrancis/Curation">005154</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000D97</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000D97</idno><idno type="wicri:doubleKey">0732-183X:2012:Gisselbrecht C:rituximab:maintenance:therapy</idno><idno type="wicri:Area/Main/Merge">005C32</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646314</idno><idno type="RBID">PMC:3646314</idno><idno type="wicri:Area/Pmc/Corpus">001950</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001950</idno><idno type="wicri:Area/Pmc/Curation">001809</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001809</idno><idno type="wicri:Area/Pmc/Checkpoint">001D81</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001D81</idno><idno type="wicri:Area/Ncbi/Merge">001015</idno><idno type="wicri:Area/Ncbi/Curation">001015</idno><idno type="wicri:Area/Ncbi/Checkpoint">001015</idno><idno type="wicri:doubleKey">0732-183X:2012:Gisselbrecht C:rituximab:maintenance:therapy</idno><idno type="wicri:Area/Main/Merge">005473</idno><idno type="wicri:Area/Main/Curation">005945</idno><idno type="wicri:Area/Main/Exploration">005945</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Rituximab Maintenance Therapy After Autologous Stem-Cell Transplantation in Patients With Relapsed CD20<sup>+</sup> Diffuse Large B-Cell Lymphoma: Final Analysis of the Collaborative Trial in Relapsed Aggressive Lymphoma</title><author><name sortKey="Gisselbrecht, Christian" sort="Gisselbrecht, Christian" uniqKey="Gisselbrecht C" first="Christian" last="Gisselbrecht">Christian Gisselbrecht</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôpital Saint Louis</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schmitz, Norbert" sort="Schmitz, Norbert" uniqKey="Schmitz N" first="Norbert" last="Schmitz">Norbert Schmitz</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Asklepios Klinik St Georg</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Mounier, Nicolas" sort="Mounier, Nicolas" uniqKey="Mounier N" first="Nicolas" last="Mounier">Nicolas Mounier</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre Hospitalier Universitaire de l'Archet</s1><s2>Nice</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Singh Gill, Devinder" sort="Singh Gill, Devinder" uniqKey="Singh Gill D" first="Devinder" last="Singh Gill">Devinder Singh Gill</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Princess Alexandra Hospital</s1><s2>Woodville, South Australia</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Princess Alexandra Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Linch, David C" sort="Linch, David C" uniqKey="Linch D" first="David C." last="Linch">David C. Linch</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>University College London, Cancer Institute</s1><s2>London</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Trneny, Marek" sort="Trneny, Marek" uniqKey="Trneny M" first="Marek" last="Trneny">Marek Trneny</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Charles University General Hospital</s1><s2>Prague</s2><s3>CZE</s3><sZ>6 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Bosly, Andre" sort="Bosly, Andre" uniqKey="Bosly A" first="Andre" last="Bosly">Andre Bosly</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Universite Catholique de Louvain Mont-Godinne</s1><s2>Yvoir</s2><s3>BEL</s3><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Universite Catholique de Louvain Mont-Godinne</wicri:noRegion></affiliation></author><author><name sortKey="Milpied, Noel J" sort="Milpied, Noel J" uniqKey="Milpied N" first="Noel J." last="Milpied">Noel J. Milpied</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hôpital Haut-Leveque</s1><s2>Pessac</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Hôpital Haut-Leveque</wicri:noRegion><wicri:noRegion>Hôpital Haut-Leveque</wicri:noRegion></affiliation></author><author><name sortKey="Radford, John" sort="Radford, John" uniqKey="Radford J" first="John" last="Radford">John Radford</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>University of Manchester, Christie Hospital National Health Service Trust</s1><s2>Manchester</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Ketterer, Nicolas" sort="Ketterer, Nicolas" uniqKey="Ketterer N" first="Nicolas" last="Ketterer">Nicolas Ketterer</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Clinique Bois-Cerf</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>10 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Shpilberg, Ofer" sort="Shpilberg, Ofer" uniqKey="Shpilberg O" first="Ofer" last="Shpilberg">Ofer Shpilberg</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Davidoff Center, Rabin Medical Center, Beilinson Hospital</s1><s2>Petah Tikva</s2><s3>ISR</s3><sZ>11 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Petah Tikva</wicri:noRegion></affiliation></author><author><name sortKey="Duhrsen, Ulrich" sort="Duhrsen, Ulrich" uniqKey="Duhrsen U" first="Ulrich" last="Dührsen">Ulrich Dührsen</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Universitatsklinikum Essen, Essen; Andreas Viardot, Universitätsklinik Ulm</s1><s2>Ulm</s2><s3>DEU</s3><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Hagberg, Hans" sort="Hagberg, Hans" uniqKey="Hagberg H" first="Hans" last="Hagberg">Hans Hagberg</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Akademiska Sjukhuset</s1><s2>Uppsala</s2><s3>SWE</s3><sZ>13 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Akademiska Sjukhuset</wicri:noRegion></affiliation></author><author><name sortKey="Ma, David D" sort="Ma, David D" uniqKey="Ma D" first="David D." last="Ma">David D. Ma</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>St Vincent's Hospital Sydney</s1><s2>Darlinghurst, New South Wales</s2><s3>AUS</s3><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>St Vincent's Hospital Sydney</wicri:noRegion></affiliation></author><author><name sortKey="Viardot, Andreas" sort="Viardot, Andreas" uniqKey="Viardot A" first="Andreas" last="Viardot">Andreas Viardot</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôpital Saint Louis</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lowenthal, Ray" sort="Lowenthal, Ray" uniqKey="Lowenthal R" first="Ray" last="Lowenthal">Ray Lowenthal</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Royal Hobart Hospital</s1><s2>Tasmania</s2><s3>AUS</s3><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Royal Hobart Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Briere, Josette" sort="Briere, Josette" uniqKey="Briere J" first="Josette" last="Briere">Josette Briere</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôpital Saint Louis</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>15 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Hospices Civils de Lyon and Universite de Lyon</s1><s2>Lyon</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Moskowitz, Craig H" sort="Moskowitz, Craig H" uniqKey="Moskowitz C" first="Craig H." last="Moskowitz">Craig H. Moskowitz</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Memorial Sloan-Kettering Cancer Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Memorial Sloan-Kettering Cancer Center</wicri:noRegion></affiliation></author><author><name sortKey="Glass, Bertram" sort="Glass, Bertram" uniqKey="Glass B" first="Bertram" last="Glass">Bertram Glass</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Asklepios Klinik St Georg</s1><s2>Hamburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of clinical oncology</title><title level="j" type="abbreviated">J. clin. oncol.</title><idno type="ISSN">0732-183X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of clinical oncology</title><title level="j" type="abbreviated">J. clin. oncol.</title><idno type="ISSN">0732-183X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic agent</term><term>Autologous hematopoietic stem cell transplantation</term><term>B cell neoplasm</term><term>Cancerology</term><term>Clinical trial</term><term>Diffuse large B cell lymphoma</term><term>Hematopoietic cell</term><term>High malignancy</term><term>Human</term><term>Immunotherapy</term><term>Lymphoid neoplasm</term><term>Maintenance treatment</term><term>Relapse</term><term>Rituximab</term><term>Stem cell</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Rituximab</term><term>Traitement entretien</term><term>Cellule hématopoïétique</term><term>Lymphome diffus à grandes cellules B</term><term>Cellule souche</term><term>Homme</term><term>Immunothérapie</term><term>Récidive</term><term>Essai clinique</term><term>Haute malignité</term><term>Cancérologie</term><term>Anticancéreux</term><term>Antigène CD20</term><term>Autogreffe de cellules souches hématopoïétiques</term><term>Hémopathie lymphoïde B</term><term>Hémopathie maligne lymphoïde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose The standard treatment for relapsed diffuse large B-cell lymphoma (DLBCL) is salvage chemotherapy followed by high-dose therapy and autologous stem-cell transplantation (ASCT). The impact of maintenance rituximab after ASCT is not known. Patients and Methods In total, 477 patients with CD20<sup>+</sup> DLBCL who were in their first relapse or refractory to initial therapy were randomly assigned to one of two salvage regimens. After three cycles of salvage chemotherapy, the responding patients received high-dose chemotherapy followed by ASCT. Then, 242 patients were randomly assigned to either rituximab every 2 months for 1 year or observation. Results After ASCT, 122 patients received rituximab, and 120 patients were observed only. The median follow-up time was 44 months. The 4-year event-free survival (EFS) rates after ASCT were 52% and 53% for the rituximab and observation groups, respectively (P = .7). Treatment with rituximab was associated with a 15% attributable risk of serious adverse events after day 100, with more deaths (six deaths v three deaths in the observation arm). Several factors affected EFS after ASCT (P< .05), including relapsed disease within 12 months (EFS: 46% v 56% for relapsed disease after 12 months), secondary age-adjusted International Prognostic Index (saalPI) more than 1 (EFS: 37% v 61 % for saalPI < 1), and prior treatment with rituximab (EFS: 47% v 59% for no prior rituximab). A significant difference in EFS between women (63%) and men (46%) was also observed in the rituximab group. In the Cox model for maintenance, the saalPI was a significant prognostic factor (P < .001), as was male sex (P = .01). Conclusion In relapsed DLBCL, we observed no difference between the control group and the rituximab maintenance group and do not recommend rituximab after ASCT.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Israël</li><li>Royaume-Uni</li><li>République tchèque</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Bohême centrale</li><li>Canton de Vaud</li><li>District de Tübingen</li><li>Grand Londres</li><li>Grand Manchester</li><li>Hambourg</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Hambourg</li><li>Lausanne</li><li>Londres</li><li>Lyon</li><li>Manchester</li><li>Nice</li><li>Paris</li><li>Prague</li><li>Ulm</li></settlement><orgName><li>University College de Londres</li><li>Université de Manchester</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Gisselbrecht, Christian" sort="Gisselbrecht, Christian" uniqKey="Gisselbrecht C" first="Christian" last="Gisselbrecht">Christian Gisselbrecht</name></region><name sortKey="Briere, Josette" sort="Briere, Josette" uniqKey="Briere J" first="Josette" last="Briere">Josette Briere</name><name sortKey="Milpied, Noel J" sort="Milpied, Noel J" uniqKey="Milpied N" first="Noel J." last="Milpied">Noel J. Milpied</name><name sortKey="Mounier, Nicolas" sort="Mounier, Nicolas" uniqKey="Mounier N" first="Nicolas" last="Mounier">Nicolas Mounier</name><name sortKey="Salles, Gilles" sort="Salles, Gilles" uniqKey="Salles G" first="Gilles" last="Salles">Gilles Salles</name><name sortKey="Viardot, Andreas" sort="Viardot, Andreas" uniqKey="Viardot A" first="Andreas" last="Viardot">Andreas Viardot</name></country><country name="Allemagne"><region name="Hambourg"><name sortKey="Schmitz, Norbert" sort="Schmitz, Norbert" uniqKey="Schmitz N" first="Norbert" last="Schmitz">Norbert Schmitz</name></region><name sortKey="Duhrsen, Ulrich" sort="Duhrsen, Ulrich" uniqKey="Duhrsen U" first="Ulrich" last="Dührsen">Ulrich Dührsen</name><name sortKey="Glass, Bertram" sort="Glass, Bertram" uniqKey="Glass B" first="Bertram" last="Glass">Bertram Glass</name></country><country name="Australie"><noRegion><name sortKey="Singh Gill, Devinder" sort="Singh Gill, Devinder" uniqKey="Singh Gill D" first="Devinder" last="Singh Gill">Devinder Singh Gill</name></noRegion><name sortKey="Lowenthal, Ray" sort="Lowenthal, Ray" uniqKey="Lowenthal R" first="Ray" last="Lowenthal">Ray Lowenthal</name><name sortKey="Ma, David D" sort="Ma, David D" uniqKey="Ma D" first="David D." last="Ma">David D. Ma</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Linch, David C" sort="Linch, David C" uniqKey="Linch D" first="David C." last="Linch">David C. Linch</name></region><name sortKey="Radford, John" sort="Radford, John" uniqKey="Radford J" first="John" last="Radford">John Radford</name></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Trneny, Marek" sort="Trneny, Marek" uniqKey="Trneny M" first="Marek" last="Trneny">Marek Trneny</name></region></country><country name="Belgique"><noRegion><name sortKey="Bosly, Andre" sort="Bosly, Andre" uniqKey="Bosly A" first="Andre" last="Bosly">Andre Bosly</name></noRegion></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Ketterer, Nicolas" sort="Ketterer, Nicolas" uniqKey="Ketterer N" first="Nicolas" last="Ketterer">Nicolas Ketterer</name></region></country><country name="Israël"><noRegion><name sortKey="Shpilberg, Ofer" sort="Shpilberg, Ofer" uniqKey="Shpilberg O" first="Ofer" last="Shpilberg">Ofer Shpilberg</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Hagberg, Hans" sort="Hagberg, Hans" uniqKey="Hagberg H" first="Hans" last="Hagberg">Hans Hagberg</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Moskowitz, Craig H" sort="Moskowitz, Craig H" uniqKey="Moskowitz C" first="Craig H." last="Moskowitz">Craig H. Moskowitz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005945 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005945 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:13-0049270
|texte= Rituximab Maintenance Therapy After Autologous Stem-Cell Transplantation in Patients With Relapsed CD20+ Diffuse Large B-Cell Lymphoma: Final Analysis of the Collaborative Trial in Relapsed Aggressive Lymphoma
}}
| This area was generated with Dilib version V0.6.33. |  |